The role of vitamin E acetate (VEA) and its derivatives in the vaping associated lung injury: systematic review of evidence

Small scale observational evidence suggested that Vitamin E (VE) might play beneficial role in human and animal respiratory conditions of various origin by stabilizing surfactant functions. The intra-aleveolar VE level is directly proportionate to the lung’s response inflammation. Electronic cigarette or vaping associated lung injury was a dominantly syndrome United States with seemingly strong association between potential acetate inhalation exposure onset symptoms. This systematic review intended assess if there previous any respiratory/gastrointestinal toxicity its derivatives. A constructed prospectively registered at PROSPERO search important clinical databases 2000 2020 for full text articles investigating effect VEA derivatives administered via route (oral/parenteral/aerosolised) adults conditions. Out 363 records and/or derivatives/isomers (any) (inflammatory, oxidative, infective, asthma/COPD) seven qualified. papers reported surrogate outcomes (APACHEII score, spirometry, etc) equivocal results. There one case report harmful both (intramuscular) (topical). present found neither harm nor significant improvement administration adult inflammatory however, were low-level evidence. Further studies are needed correct flaws research explore pulmonology.